[PTYR705]-STAT3
SuberoylBis-hydroxamicAcid(SuberoylBis-hydroxamicAcid)
CAS: 38937-66-5
化学式: C8H16N2O4
| 中文名 | SuberoylBis-hydroxamicAcid |
| 英文名 | SuberoylBis-hydroxamicAcid |
| 别名 | 软木肟酸 次异羟肟酸 辛烷-1,8-二氧肟酸 N1,N8-二羟基辛烷二酰胺 |
| 英文别名 | ODHA SBHA STAT3 (PTYR705) [PTYR705]-STAT3 SUBEROHYDROXAMIC ACID Suberohydroxamic acid SUBERIC BISHYDROXAMATE SuberoylBis-hydroxamicAcid SUBEROYL BISHYDROXAMIC ACID OCTANE-1,8-DIHYDROXAMIC ACID |
| CAS | 38937-66-5 |
| 化学式 | C8H16N2O4 |
| 分子量 | 204.22 |
| 熔点 | 153-155°C(lit.) |
| 溶解度 | H2O: 可溶 |
| 存储条件 | −20°C |
| 稳定性 | 吸湿性 |
| 外观 | 冻干粉 |
| 颜色 | White to Light Beige |
| MDL号 | MFCD00192455 |
| 体外研究 | Suberoyl bis-hydroxamic acid (10, 20 or 50 μM; 24 hours) combination with TRAIL improves apoptosis extent, and when TRAIL is combined with 20 μM SBHA (itself causing only 10–15% apoptosis), resulting in 45–50% cell death.Suberoyl bis-hydroxamic acid (20-50 μM; 10-20 hours) alone has little effect on the expression of the proteins Bcl-xL, Mcl-1, and has albeit mildeffect on Bax. When it combines with TRAIL,which increases the ratio of relative protein expression of Bcl-xL and Bax in early periods, while the change in the ratio of Mcl-1 and Bax increases later in MM-BI and Ist-Mes2 cells.Suberoyl bis-hydroxamic acid (30 μM; 6 hours) causes accumulation of acetylated histone H4 in MEL cells. Apoptosis Analysis Cell Line: MM-BI and Ist-Mes2 cells Concentration: 10 μM, 20 μM or 50 μM Incubation Time: 24 hours Result: Showed a cooperative effect in cell apoptosis. |
| 体内研究 | Suberoyl bis-hydroxamic acid (intraperitoneal injection; 200 mg/kg; every 2 days; 12 days) reveals a marked increase in the active form of Notch1 (NICD) with a concomitant decrease in ASCL1. It reduces the MTC tumor growth. Animal Model: Nude mice injected with human MTC cells Dosage: 200 mg/kg Administration: Intraperitoneal injection; every 2 days; 12 days Result: Resulted in an average 55% inhibition of tumor growth in SBHA treatment group. |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 3 |
![[PTYR705]-STAT3](http://res.chembk.com/assets/images/structure/306731.gif)
供应商列表
现货供应
产品名: Suberoyl bis-hydroxamic acid 去供应商网站查看 询盘CAS: 38937-66-5
产地: 美国
包装: 10 mM * 1 mL;50 mg;100 mg;250 mg
规格: HY-W009776
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: ≥98.0%
产品名: SuberoylBis-hydroxamicAcid 去供应商网站查看 询盘
CAS: 38937-66-5
产地: 上海
规格: 95%
价格: 1g 670,5g 2300
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: SuberoylBis-hydroxamicAcid 95% 源叶 货号：Y35927
CAS: 38937-66-5
产地: 上海
规格: 95%
价格: 1g 670,5g 2300
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: SuberoylBis-hydroxamicAcid 95% 源叶 货号：Y35927
现货供应
产品名: Suberoyl bis-hydroxamic acid 去供应商网站查看 询盘CAS: 38937-66-5
产地: 美国
包装: 10 mM * 1 mL;50 mg;100 mg;250 mg
规格: HY-W009776
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: ≥98.0%
产品名: SuberoylBis-hydroxamicAcid 去供应商网站查看 询盘
CAS: 38937-66-5
产地: 上海
规格: 95%
价格: 1g 670,5g 2300
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: SuberoylBis-hydroxamicAcid 95% 源叶 货号：Y35927
CAS: 38937-66-5
产地: 上海
规格: 95%
价格: 1g 670,5g 2300
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: SuberoylBis-hydroxamicAcid 95% 源叶 货号：Y35927
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